Ube3c | ubiquitin protein ligase E3C

Physiological systems

20 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Muscle Nervous system Vision/eye Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

8 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:29Significant phenotypes

1Associated diseases

Expression examined in:152Adult tissues

25Embryo tissues

Phenotypes

Phy. System:

Life Stage:



increased cardiac muscle contractility	2 supporting datasets	Ube3c^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	2.68x10^-6
decreased circulating serum albumin level	1 supporting dataset	Ube3c^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.99x10^-5
decreased prepulse inhibition	3 supporting datasets	Ube3c^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.29x10^-7
increased circulating alkaline phosphatase level	2 supporting datasets	Ube3c^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.96x10^-9
increased total body fat amount	1 supporting dataset	Ube3c^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.86x10^-5
increased effector memory CD8-positive, alpha-beta T cell number	1 supporting dataset	Ube3c^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.44x10^-5
decreased Ly6C-positive NK T cell number	1 supporting dataset	Ube3c^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.45x10^-6
decreased body length	2 supporting datasets	Ube3c^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.94x10^-6
decreased exploration in new environment	2 supporting datasets	Ube3c^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.22x10^-8
decreased locomotor activity	2 supporting datasets	Ube3c^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.18x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ube3c.

Associated images

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Histopathology

There is no histopathology data found for Ube3c.

IMPC related publications

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External links

No external links available for Ube3c.

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*Ube3c^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ube3c^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ube3c^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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