Ttc28 | tetratricopeptide repeat domain 28

GeneMGI:2140873Synonyms: TPRBK, 2310015L07Rik

Physiological systems

17 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Limbs/digits/tail Nervous system Hematopoietic system Behavior/neurological Skeleton Mortality/aging Craniofacial

7 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:22Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased circulating cholesterol level	1 supporting dataset	Ttc28^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.05x10^-8
vertebral fusion	1 supporting dataset	Ttc28^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.24x10^-12
decreased bone mineral density	1 supporting dataset	Ttc28^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.64x10^-5
decreased body length	1 supporting dataset	Ttc28^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.72x10^-10
abnormal vertebrae morphology	1 supporting dataset	Ttc28^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.24x10^-12
abnormal maxilla morphology	1 supporting dataset	Ttc28^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.26x10^-13
decreased prepulse inhibition	2 supporting datasets	Ttc28^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.17x10^-6
increased lymphocyte cell number	1 supporting dataset	Ttc28^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.67x10^-5
increased grip strength	1 supporting dataset	Ttc28^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.12x10^-14
abnormal cranium morphology	1 supporting dataset	Ttc28^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.41x10^-12

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ttc28.

Associated images

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Histopathology

There is no histopathology data found for Ttc28.

IMPC related publications

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External links

No external links available for Ttc28.

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*Ttc28^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ttc28^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ttc28^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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