Nsun5 | NOL1/NOP2/Sun domain family, member 5

GeneMGI:2140844Synonyms: Wbscr20a, 9830109N13Rik, +1 more

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:49Adult tissues

50Embryo tissues

Phenotypes

Phy. System:

Life Stage:



decreased thigmotaxis	2 supporting datasets	Nsun5^{tm2b(EUCOMM)Wtsi}	homozygote	Late adult	6.97x10^-5
decreased hemoglobin content	1 supporting dataset	Nsun5^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	2.34x10^-11
decreased hematocrit	1 supporting dataset	Nsun5^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	6.21x10^-14
decreased locomotor activity	4 supporting datasets	Nsun5^{tm2b(EUCOMM)Wtsi}	homozygote	Late adult	1.19x10^-6
abnormal behavior	1 supporting dataset	Nsun5^{tm2b(EUCOMM)Wtsi}	homozygote	Late adult	7.62x10^-5
decreased erythrocyte cell number	1 supporting dataset	Nsun5^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	4.33x10^-11
impaired pupillary reflex	1 supporting dataset	Nsun5^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	2.53x10^-6
thrombocytopenia	2 supporting datasets	Nsun5^{tm2b(EUCOMM)Wtsi}	homozygote	Late adult	3.79x10^-7
decreased lymphocyte cell number	1 supporting dataset	Nsun5^{tm2b(EUCOMM)Wtsi}	homozygote	Late adult	2.87x10^-6
increased circulating alanine transaminase level	1 supporting dataset	Nsun5^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	2.33x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nsun5.

Associated images

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Histopathology

There is no histopathology data found for Nsun5.

IMPC related publications

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External links

No external links available for Nsun5.

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*Nsun5^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Nsun5^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Nsun5^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Nsun5^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Nsun5^{tm2b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Nsun5^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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