Lrrc8c | leucine rich repeat containing 8 family, member C

GeneMGI:2140839Synonyms: E430036I04Rik

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Vision/eye Hematopoietic system Mortality/aging

13 No significant impact

4 Not tested

Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased circulating calcium level1 supporting datasetLrrc8cem1(IMPC)MbphomozygoteEarly adult3.55x10-6 
abnormal eye morphology1 supporting datasetLrrc8cem1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal spleen morphology1 supporting datasetLrrc8cem1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal testis morphology1 supporting datasetLrrc8cem1(IMPC)MbphomozygoteEarly adultN/A * 
small testis1 supporting datasetLrrc8cem1(IMPC)MbphomozygoteEarly adultN/A * 
decreased circulating serum albumin level1 supporting datasetLrrc8cem1(IMPC)MbphomozygoteEarly adult9.78x10-5 
preweaning lethality, incomplete penetrance1 supporting datasetLrrc8cem1(IMPC)MbphomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Lrrc8cem1(IMPC)MbpExon Deletionmouse

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