Wdr47 | WD repeat domain 47

GeneMGI:2139593Synonyms: nemitin, 1810073M12Rik

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Integument Growth/size/body region Hematopoietic system Behavior/neurological

15 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased grip strength	2 supporting datasets	Wdr47^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.01x10^-8
limb grasping	1 supporting dataset	Wdr47^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.43x10^-7
increased circulating alkaline phosphatase level	1 supporting dataset	Wdr47^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.65x10^-5
abnormal skin pigmentation	1 supporting dataset	Wdr47^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.33x10^-5
decreased circulating LDL cholesterol level	1 supporting dataset	Wdr47^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.31x10^-5
decreased mean corpuscular hemoglobin	1 supporting dataset	Wdr47^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.16x10^-6
decreased body weight	1 supporting dataset	Wdr47^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.33x10^-10
hyperactivity	1 supporting dataset	Wdr47^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6x10^-6
decreased hemoglobin content	1 supporting dataset	Wdr47^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.96x10^-5
abnormal skin morphology	1 supporting dataset	Wdr47^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.96x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Wdr47.

Associated images

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Histopathology

There is no histopathology data found for Wdr47.

IMPC related publications

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External links

No external links available for Wdr47.

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*Wdr47^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Wdr47^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Wdr47^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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