Eps8l2 | EPS8-like 2

Physiological systems

16 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Nervous system Hearing/vestibular/ear Hematopoietic system Behavior/neurological Craniofacial

8 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:17Significant phenotypes

2Associated diseases

Expression examined in:46Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased circulating fructosamine level	1 supporting dataset	Eps8l2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.63x10^-6
increased mean corpuscular hemoglobin	1 supporting dataset	Eps8l2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.55x10^-5
decreased erythrocyte cell number	1 supporting dataset	Eps8l2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.78x10^-5
decreased circulating calcium level	1 supporting dataset	Eps8l2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.6x10^-5
increased monocyte cell number	2 supporting datasets	Eps8l2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.49x10^-8
abnormal startle reflex	1 supporting dataset	Eps8l2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.66x10^-9
decreased circulating serum albumin level	1 supporting dataset	Eps8l2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.96x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Eps8l2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9.12x10^-5
decreased prepulse inhibition	5 supporting datasets	Eps8l2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.6x10^-10
impaired cued conditioning behavior	1 supporting dataset	Eps8l2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9.56x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Eps8l2.

Associated images

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Histopathology

There is no histopathology data found for Eps8l2.

IMPC related publications

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External links

No external links available for Eps8l2.

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*Eps8l2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Eps8l2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Eps8l2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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