Phlpp1 | PH domain and leucine rich repeat protein phosphatase 1

GeneMGI:2138327Synonyms: Plekhe1, Phlpp

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Growth/size/body region Vision/eye Behavior/neurological Cardiovascular system

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



abnormal retina outer nuclear layer morphology	2 supporting datasets	Phlpp1^em1(IMPC)Bay	homozygote	Early adult	1.48x10^-21
abnormal retina outer nuclear layer morphology	1 supporting dataset	Phlpp1^em1(IMPC)Bay	homozygote	Late adult	1.85x10^-6
decreased lean body mass	1 supporting dataset	Phlpp1^em1(IMPC)Bay	homozygote	Late adult	1.32x10^-8
decreased locomotor activity	1 supporting dataset	Phlpp1^em1(IMPC)Bay	homozygote	Late adult	7.44x10^-5
abnormal retina vasculature morphology	1 supporting dataset	Phlpp1^em1(IMPC)Bay	homozygote	Late adult	2.45x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Phlpp1.

Associated images

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Histopathology

There is no histopathology data found for Phlpp1.

IMPC related publications

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External links

No external links available for Phlpp1.

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*Phlpp1^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Phlpp1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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