Lbr | lamin B receptor

Physiological systems

18 / 24 physiological systems tested

14 Significantly impacted by the knock-out

Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Hematopoietic system Craniofacial Homeostasis/metabolism Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton Mortality/aging

4 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:31Significant phenotypes

7Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased body length	1 supporting dataset	Lbr^em1(IMPC)Tcp	homozygote	Early adult	0
decreased exploration in new environment	2 supporting datasets	Lbr^em1(IMPC)Tcp	homozygote	Early adult	2.35x10^-10
abnormal coat/ hair morphology	3 supporting datasets	Lbr^em1(IMPC)Tcp	homozygote	Early adult	7.4x10^-16
abnormal digit morphology	2 supporting datasets	Lbr^em1(IMPC)Tcp	homozygote	Early adult	1.68x10^-14
decreased prepulse inhibition	4 supporting datasets	Lbr^em1(IMPC)Tcp	homozygote	Early adult	2.89x10^-15
abnormal skin morphology	3 supporting datasets	Lbr^em1(IMPC)Tcp	homozygote	Early adult	3.81x10^-7
decreased grip strength	4 supporting datasets	Lbr^em1(IMPC)Tcp	homozygote	Early adult	0
decreased locomotor activity	2 supporting datasets	Lbr^em1(IMPC)Tcp	homozygote	Early adult	0
decreased circulating alkaline phosphatase level	1 supporting dataset	Lbr^em1(IMPC)Tcp	homozygote	Early adult	2.23x10^-9
abnormal cranium morphology	1 supporting dataset	Lbr^em1(IMPC)Tcp	homozygote	Early adult	1.69x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lbr.

Associated images

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Histopathology

There is no histopathology data found for Lbr.

IMPC related publications

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External links

No external links available for Lbr.

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*Lbr^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Lbr^tm1(KOMP)Mbp*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Lbr^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell

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