Cwc22 | CWC22 spliceosome-associated protein

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Embryo Nervous system Liver/biliary system Hematopoietic system Skeleton Cardiovascular system Mortality/aging Renal/urinary system

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



cystolithiasis	1 supporting dataset	Cwc22^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
spina bifida	1 supporting dataset	Cwc22^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
abnormal spleen morphology	1 supporting dataset	Cwc22^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
abnormal liver morphology	2 supporting datasets	Cwc22^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
urinary bladder obstruction	1 supporting dataset	Cwc22^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Cwc22^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
prenatal lethality prior to heart atrial septation	1 supporting dataset	Cwc22^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Cwc22^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased circulating aspartate transaminase level	1 supporting dataset	Cwc22^em1(IMPC)Mbp	heterozygote	Late adult	3.48x10^-5
hemorrhage	1 supporting dataset	Cwc22^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cwc22.

Associated images

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Histopathology

There is no histopathology data found for Cwc22.

IMPC related publications

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External links

No external links available for Cwc22.

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*Cwc22^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Cwc22^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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