Cers1 | ceramide synthase 1

GeneMGI:2136690Synonyms: CerS1, Lass1, +2 more

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Immune system Hematopoietic system Mortality/aging

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:2Significant phenotypes

7Associated diseases

Expression examined in:46Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, incomplete penetrance	1 supporting dataset	Cers1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased neutrophil cell number	1 supporting dataset	Cers1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.76x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cers1.

Associated images

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Histopathology

There is no histopathology data found for Cers1.

IMPC related publications

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External links

No external links available for Cers1.

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*Cers1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Cers1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cers1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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