Vangl2 | VANGL planar cell polarity 2

GeneMGI:2135272Synonyms: ska<m17Jus>, Lpp1, +6 more

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Digestive/alimentary Limbs/digits/tail Vision/eye Nervous system Behavior/neurological Craniofacial Mortality/aging

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:19Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



abnormal head shape	1 supporting dataset	Vangl2^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal placenta morphology	1 supporting dataset	Vangl2^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
decreased circulating HDL cholesterol level	1 supporting dataset	Vangl2^Lp	heterozygote	Early adult	2.88x10^-5
abnormal craniofacial morphology	1 supporting dataset	Vangl2^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal snout morphology	1 supporting dataset	Vangl2^Lp	heterozygote	Early adult	5.08x10^-7
preweaning lethality, complete penetrance	1 supporting dataset	Vangl2^Lp	homozygote	Early adult	N/A ^*
abnormal retina morphology	1 supporting dataset	Vangl2^em1(IMPC)Mbp	heterozygote	Early adult	1.08x10^-6
decreased circulating cholesterol level	2 supporting datasets	Vangl2^Lp	heterozygote	Early adult	5.94x10^-11
exencephaly	1 supporting dataset	Vangl2^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal tail morphology	1 supporting dataset	Vangl2^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Vangl2.

Associated images

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Histopathology

There is no histopathology data found for Vangl2.

IMPC related publications

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External links

No external links available for Vangl2.

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*Vangl2^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Vangl2^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Vangl2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Vangl2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Vangl2^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Vangl2^{tm3a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Vangl2^{tm3e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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