Mllt6 | myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6

GeneMGI:1935145Synonyms: Af17

Physiological systems

20 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Digestive/alimentary Nervous system Liver/biliary system Hematopoietic system Behavior/neurological Skeleton

9 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



increased neutrophil cell number	1 supporting dataset	Mllt6^em1(IMPC)Tcp	homozygote	Late adult	9.61x10^-5
decreased prepulse inhibition	6 supporting datasets	Mllt6^em1(IMPC)Tcp	homozygote	Early adult	1.76x10^-8
decreased bone mineral density	1 supporting dataset	Mllt6^em1(IMPC)Tcp	homozygote	Late adult	1.81x10^-9
abnormal stomach morphology	1 supporting dataset	Mllt6^em1(IMPC)Tcp	homozygote	Late adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Mllt6^em1(IMPC)Tcp	homozygote	Late adult	N/A ^*
abnormal uterus morphology	1 supporting dataset	Mllt6^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
increased mean platelet volume	1 supporting dataset	Mllt6^em1(IMPC)Tcp	homozygote	Late adult	5.4x10^-6
enlarged spleen	1 supporting dataset	Mllt6^em1(IMPC)Tcp	homozygote	Late adult	N/A ^*
decreased lymphocyte cell number	2 supporting datasets	Mllt6^em1(IMPC)Tcp	homozygote	Late adult	4.89x10^-5
abnormal skin morphology	1 supporting dataset	Mllt6^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mllt6.

Associated images

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Histopathology

There is no histopathology data found for Mllt6.

IMPC related publications

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External links

No external links available for Mllt6.

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*Mllt6^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Mllt6^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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