Nucks1 | nuclear casein kinase and cyclin-dependent kinase substrate 1

GeneMGI:1934811Synonyms: 2700010L10Rik, 8430423A01Rik, +1 more

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Growth/size/body region Digestive/alimentary Vision/eye Hematopoietic system Behavior/neurological Mortality/aging Renal/urinary system

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



abnormal vibrissa morphology	1 supporting dataset	Nucks1^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	1.54x10^-5
increased leukocyte cell number	1 supporting dataset	Nucks1^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	7.06x10^-8
abnormal eye morphology	1 supporting dataset	Nucks1^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*
increased lean body mass	1 supporting dataset	Nucks1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.22x10^-5
decreased grip strength	1 supporting dataset	Nucks1^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	7.35x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Nucks1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal jejunum morphology	1 supporting dataset	Nucks1^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*
decreased circulating HDL cholesterol level	1 supporting dataset	Nucks1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.92x10^-5
enlarged lymph nodes	1 supporting dataset	Nucks1^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Nucks1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nucks1.

Associated images

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Histopathology

There is no histopathology data found for Nucks1.

IMPC related publications

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External links

No external links available for Nucks1.

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*Nucks1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Nucks1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Nucks1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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