Setdb1 | SET domain, bifurcated 1

GeneMGI:1934229Synonyms: KMT1E, ESET

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Immune system Hematopoietic system Behavior/neurological Skeleton Mortality/aging

16 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	2 supporting datasets	Setdb1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased startle reflex	1 supporting dataset	Setdb1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	7.84x10^-14
increased CD4-positive, alpha-beta T cell number	1 supporting dataset	Setdb1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	6.09x10^-7
increased bone mineral density	1 supporting dataset	Setdb1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.38x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Setdb1.

Associated images

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Histopathology

There is no histopathology data found for Setdb1.

IMPC related publications

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External links

No external links available for Setdb1.

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*Setdb1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse

My Genes