Nedd4l | neural precursor cell expressed, developmentally down-regulated gene 4-like

GeneMGI:1933754Synonyms: Nedd4-2, 1300012C07Rik, +1 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Hearing/vestibular/ear Nervous system Vision/eye Behavior/neurological Mortality/aging

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



decreased exploration in new environment	1 supporting dataset	Nedd4l^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.84x10^-5
abnormal retina morphology	1 supporting dataset	Nedd4l^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.12x10^-11
abnormal auditory brainstem response	6 supporting datasets	Nedd4l^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.53x10^-8
decreased prepulse inhibition	6 supporting datasets	Nedd4l^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.82x10^-10
preweaning lethality, incomplete penetrance	1 supporting dataset	Nedd4l^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal startle reflex	1 supporting dataset	Nedd4l^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.84x10^-13
decreased startle reflex	1 supporting dataset	Nedd4l^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.63x10^-5
decreased locomotor activity	1 supporting dataset	Nedd4l^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9.68x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nedd4l.

Associated images

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Histopathology

There is no histopathology data found for Nedd4l.

IMPC related publications

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External links

No external links available for Nedd4l.

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*Nedd4l^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Nedd4l^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Nedd4l^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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