Erap1 | endoplasmic reticulum aminopeptidase 1

GeneMGI:1933403Synonyms: ERAAP, PILSAP, +1 more

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Liver/biliary system Hematopoietic system Behavior/neurological Skeleton

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



abnormal liver morphology	1 supporting dataset	Erap1^{tm2b(EUCOMM)Wtsi}	homozygote	Late adult	N/A ^*
decreased bone mineral content	2 supporting datasets	Erap1^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	1.69x10^-5
hyperactivity	3 supporting datasets	Erap1^{tm2b(EUCOMM)Wtsi}	homozygote	Late adult	1.38x10^-7
decreased total body fat amount	1 supporting dataset	Erap1^{tm2b(EUCOMM)Wtsi}	homozygote	Late adult	8.43x10^-5
decreased circulating serum albumin level	1 supporting dataset	Erap1^{tm2b(EUCOMM)Wtsi}	homozygote	Late adult	1.09x10^-5
increased circulating calcium level	1 supporting dataset	Erap1^{tm2b(EUCOMM)Wtsi}	homozygote	Late adult	8.67x10^-5
thrombocytosis	1 supporting dataset	Erap1^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	4.33x10^-5
increased lean body mass	1 supporting dataset	Erap1^{tm2b(EUCOMM)Wtsi}	homozygote	Late adult	7.2x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Erap1.

Associated images

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Histopathology

There is no histopathology data found for Erap1.

IMPC related publications

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External links

No external links available for Erap1.

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*Erap1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Erap1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Erap1^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Erap1^{tm2b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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