Bicc1 | BicC family RNA binding protein 1

GeneMGI:1933388Synonyms: jcpk, Bic-C

Physiological systems

22 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Embryo Behavior/neurological Mortality/aging Cardiovascular system Renal/urinary system

16 No significant impact

2 Not tested

Gene metrics:12Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal heart morphology1 supporting datasetBicc1em1(IMPC)MbphomozygoteE9.5N/A * 
abnormal heart looping1 supporting datasetBicc1em1(IMPC)MbphomozygoteE9.5N/A * 
abnormal placenta vasculature1 supporting datasetBicc1em1(IMPC)MbphomozygoteE15.5N/A * 
preweaning lethality, complete penetrance1 supporting datasetBicc1em1(IMPC)MbphomozygoteEarly adultN/A * 
edema1 supporting datasetBicc1em1(IMPC)MbphomozygoteE15.5N/A * 
decreased locomotor activity1 supporting datasetBicc1em1(IMPC)MbpheterozygoteEarly adult1.36x10-8 
abnormal blood vessel morphology1 supporting datasetBicc1em1(IMPC)MbpheterozygoteE15.5N/A * 
preweaning lethality, incomplete penetrance2 supporting datasetsBicc1em1(IMPC)MbphomozygoteEarly adultN/A * 
small kidney1 supporting datasetBicc1em1(IMPC)MbpheterozygoteEarly adultN/A * 
abnormal placenta morphology1 supporting datasetBicc1em1(IMPC)MbphomozygoteE15.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Bicc1em1(IMPC)MbpExon Deletionmouse
Bicc1tm43183(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Bicc1tm43183(L1L2_gt1)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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