Sacm1l | SAC1 suppressor of actin mutations 1-like (yeast)

GeneMGI:1933169Synonyms: Sac1p, SAC1

Physiological systems

22 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Reproductive system Endocrine/exocrine gland Behavior/neurological Mortality/aging

18 No significant impact

2 Not tested

Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
30Embryo tissues

Phenotypes

decreased thigmotaxis2 supporting datasetsSacm1ltm1b(KOMP)WtsiheterozygoteEarly adult2.01x10-5 
preweaning lethality, complete penetrance3 supporting datasetsSacm1ltm1b(KOMP)WtsihomozygoteEarly adultN/A * 
enlarged epididymis1 supporting datasetSacm1ltm1b(KOMP)WtsiheterozygoteEarly adultN/A * 
abnormal epididymis morphology1 supporting datasetSacm1ltm1b(KOMP)WtsiheterozygoteEarly adultN/A * 
embryonic lethality prior to organogenesis1 supporting datasetSacm1ltm1b(KOMP)WtsihomozygoteE9.5N/A * 
hyperactivity1 supporting datasetSacm1ltm1b(KOMP)WtsiheterozygoteEarly adult4.89x10-5 
small testis1 supporting datasetSacm1ltm1b(KOMP)WtsiheterozygoteEarly adultN/A * 
embryonic lethality prior to tooth bud stage1 supporting datasetSacm1ltm1b(KOMP)WtsihomozygoteE12.5N/A * 
abnormal testis morphology1 supporting datasetSacm1ltm1b(KOMP)WtsiheterozygoteEarly adultN/A * 
abnormal behavior1 supporting datasetSacm1ltm1b(KOMP)WtsiheterozygoteEarly adult2.01x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Sacm1ltm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Sacm1ltm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Sacm1ltm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Sacm1ltm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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