Sacm1l | SAC1 suppressor of actin mutations 1-like (yeast)

GeneMGI:1933169Synonyms: Sac1p, SAC1

Physiological systems

22 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Reproductive system Endocrine/exocrine gland Behavior/neurological Mortality/aging

18 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

30Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased thigmotaxis	2 supporting datasets	Sacm1l^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.01x10^-5
preweaning lethality, complete penetrance	3 supporting datasets	Sacm1l^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
enlarged epididymis	1 supporting dataset	Sacm1l^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
abnormal epididymis morphology	1 supporting dataset	Sacm1l^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Sacm1l^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
hyperactivity	1 supporting dataset	Sacm1l^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	4.89x10^-5
small testis	1 supporting dataset	Sacm1l^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Sacm1l^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal testis morphology	1 supporting dataset	Sacm1l^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
abnormal behavior	1 supporting dataset	Sacm1l^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.01x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sacm1l.

Associated images

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Histopathology

There is no histopathology data found for Sacm1l.

IMPC related publications

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External links

No external links available for Sacm1l.

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*Sacm1l^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Sacm1l^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Sacm1l^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Sacm1l^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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