Cdk5rap3 | CDK5 regulatory subunit associated protein 3

GeneMGI:1933126Synonyms: HSF-27, C53, +4 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Behavior/neurological Mortality/aging Cardiovascular system

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased cardiac stroke volume	1 supporting dataset	Cdk5rap3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.29x10^-6
persistence of hyaloid vascular system	1 supporting dataset	Cdk5rap3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.36x10^-6
abnormal retina blood vessel morphology	1 supporting dataset	Cdk5rap3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.52x10^-9
abnormal vitreous body morphology	1 supporting dataset	Cdk5rap3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.27x10^-8
cataract	1 supporting dataset	Cdk5rap3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.93x10^-5
decreased exploration in new environment	1 supporting dataset	Cdk5rap3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.78x10^-6
abnormal retina morphology	1 supporting dataset	Cdk5rap3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.36x10^-9
abnormal lens morphology	1 supporting dataset	Cdk5rap3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.66x10^-5
increased fasting circulating glucose level	1 supporting dataset	Cdk5rap3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.3x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Cdk5rap3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cdk5rap3.

Associated images

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Histopathology

There is no histopathology data found for Cdk5rap3.

IMPC related publications

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External links

No external links available for Cdk5rap3.

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*Cdk5rap3^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Cdk5rap3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Cdk5rap3^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cdk5rap3^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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