Klb | klotho beta

GeneMGI:1932466Synonyms: betaKlotho

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Embryo Growth/size/body region Behavior/neurological Mortality/aging Cardiovascular system

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, incomplete penetrance	1 supporting dataset	Klb^em1(IMPC)J	homozygote	Early adult	N/A ^*
decreased grip strength	2 supporting datasets	Klb^em1(IMPC)J	heterozygote	Early adult	2.99x10^-7
abnormal placenta vasculature	1 supporting dataset	Klb^em1(IMPC)J	homozygote	E18.5	N/A ^*
abnormal embryo size	1 supporting dataset	Klb^em1(IMPC)J	homozygote	E18.5	N/A ^*
abnormal placenta size	1 supporting dataset	Klb^em1(IMPC)J	homozygote	E18.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Klb.

Associated images

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Histopathology

There is no histopathology data found for Klb.

IMPC related publications

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External links

No external links available for Klb.

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*Klb^em1(IMPC)J*	Exon Deletion	‌	mouse
*Klb^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Klb^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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