Phip | pleckstrin homology domain interacting protein

GeneMGI:1932404Synonyms: 4632404O06Rik, 2810004D21Rik, +2 more

Physiological systems

21 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Embryo Growth/size/body region Nervous system Hematopoietic system Behavior/neurological Skeleton Mortality/aging Craniofacial Renal/urinary system

9 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



increased circulating aspartate transaminase level	1 supporting dataset	Phip^em1(IMPC)Tcp	heterozygote	Early adult	1.15x10^-5
hyperactivity	2 supporting datasets	Phip^em1(IMPC)Tcp	heterozygote	Early adult	1.06x10^-5
hydrocephaly	1 supporting dataset	Phip^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
enlarged urinary bladder	1 supporting dataset	Phip^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Phip^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
decreased body length	1 supporting dataset	Phip^{em1(IMPC)Wtsi}	heterozygote	Early adult	3.03x10^-10
decreased circulating chloride level	1 supporting dataset	Phip^{em1(IMPC)Wtsi}	heterozygote	Early adult	6.47x10^-6
abnormal cranium morphology	1 supporting dataset	Phip^em1(IMPC)Tcp	heterozygote	Early adult	2.06x10^-6
increased leukocyte cell number	1 supporting dataset	Phip^{em1(IMPC)Wtsi}	heterozygote	Early adult	3.22x10^-5
abnormal embryo size	1 supporting dataset	Phip^em1(IMPC)Tcp	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Phip.

Associated images

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Histopathology

There is no histopathology data found for Phip.

IMPC related publications

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External links

No external links available for Phip.

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*Phip^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Phip^{em1(IMPC)Wtsi}*	Exon Deletion	‌	mouse
*Phip^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Phip^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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