Agpat1 | 1-acylglycerol-3-phosphate O-acyltransferase 1

GeneMGI:1932075Synonyms: 1-AGP, Lpaat-alpha

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Mortality/aging Cardiovascular system Renal/urinary system

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:49Adult tissues

46Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased urine glucose level	1 supporting dataset	Agpat1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	2.2x10^-6
decreased circulating calcium level	1 supporting dataset	Agpat1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	7.71x10^-7
prolonged RR interval	1 supporting dataset	Agpat1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1.68x10^-5
decreased circulating glucose level	1 supporting dataset	Agpat1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	9.06x10^-8
increased circulating alkaline phosphatase level	1 supporting dataset	Agpat1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	5.72x10^-7
increased circulating alanine transaminase level	1 supporting dataset	Agpat1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	2.18x10^-5
decreased circulating chloride level	1 supporting dataset	Agpat1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	6.41x10^-5
increased urine microalbumin level	1 supporting dataset	Agpat1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	5.83x10^-5
increased circulating potassium level	1 supporting dataset	Agpat1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	9.99x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Agpat1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Agpat1.

Associated images

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Histopathology

There is no histopathology data found for Agpat1.

IMPC related publications

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External links

No external links available for Agpat1.

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*Agpat1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Agpat1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Agpat1^{tm213685(L1L2_Bact_P)}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector

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