Dbn1 | drebrin 1

GeneMGI:1931838Synonyms: drebrin A, drebrin E2

Physiological systems

24 / 24 physiological systems tested

14 Significantly impacted by the knock-out

Immune system Integument Adipose tissue Growth/size/body region Hematopoietic system Cardiovascular system Homeostasis/metabolism Embryo Nervous system Vision/eye Liver/biliary system Behavior/neurological Skeleton Mortality/aging

10 No significant impact

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:40Significant phenotypes

0Associated diseases

Expression examined in:82Adult tissues

97Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



decreased grip strength	1 supporting dataset	Dbn1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	7.72x10^-6
unresponsive to tactile stimuli	1 supporting dataset	Dbn1^{tm1b(KOMP)Wtsi}	heterozygote	E18.5	N/A ^*
decreased mean platelet volume	1 supporting dataset	Dbn1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.76x10^-6
preweaning lethality, incomplete penetrance	10 supporting datasets	Dbn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	6 supporting datasets	Dbn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased circulating serum albumin level	2 supporting datasets	Dbn1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	8.1x10^-6
abnormal embryo size	1 supporting dataset	Dbn1^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
decreased body weight	4 supporting datasets	Dbn1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.71x10^-14
decreased total retina thickness	2 supporting datasets	Dbn1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.06x10^-5
enlarged heart	2 supporting datasets	Dbn1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dbn1.

Associated images

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Histopathology

There is no histopathology data found for Dbn1.

IMPC related publications

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External links

No external links available for Dbn1.

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*Dbn1^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Dbn1^em1(IMPC)J*	Intra-exon deletion	‌	mouse
*Dbn1^em2(IMPC)Mbp*	Insertion	‌	mouse
*Dbn1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Dbn1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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