Rab27b | RAB27B, member RAS oncogene family
Physiological systems
17 / 24 physiological systems tested
1 Significantly impacted by the knock-out
Behavior/neurological
16 No significant impact
7 Not tested
Data collections
Gene metrics:1Significant phenotypes
0Associated diseases
Expression examined in:50Adult tissues
46Embryo tissues
| abnormal sleep behavior | 2 supporting datasets | Rab27btm1b(KOMP)Wtsi | homozygote | Early adult | 1.72x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | Section images | 100% (1/1) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 50% (1/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Rab27b mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Rab27b.
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| Rab27btm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Rab27btm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Rab27btm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |