Sec61a2 | SEC61 translocon subunit alpha 2

GeneMGI:1931071

Physiological systems

17 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Behavior/neurological

15 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased grip strength	1 supporting dataset	Sec61a2^em1(IMPC)J	homozygote	Early adult	4.38x10^-5
increased startle reflex	1 supporting dataset	Sec61a2^em1(IMPC)J	homozygote	Early adult	2.34x10^-6
increased circulating phosphate level	1 supporting dataset	Sec61a2^em1(IMPC)J	homozygote	Early adult	2.24x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sec61a2.

Associated images

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Histopathology

There is no histopathology data found for Sec61a2.

IMPC related publications

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External links

No external links available for Sec61a2.

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*Sec61a2^em1(IMPC)J*	Exon Deletion	‌	mouse
*Sec61a2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Sec61a2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Sec61a2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Sec61a2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Sec61a2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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