Recql4 | RecQ protein-like 4

Physiological systems

22 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Integument Growth/size/body region Behavior/neurological Mortality/aging

18 No significant impact

2 Not tested

Gene metrics:5Significant phenotypes
6Associated diseases
Expression examined in:73Adult tissues
29Embryo tissues

Phenotypes

preweaning lethality, complete penetrance2 supporting datasetsRecql4tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
increased aggression1 supporting datasetRecql4tm1.1(KOMP)VlcgheterozygoteEarly adult8.89x10-5 
decreased body length1 supporting datasetRecql4tm1.1(KOMP)VlcgheterozygoteEarly adult3.5x10-6 
abnormal coat/ hair morphology1 supporting datasetRecql4tm1.1(KOMP)VlcgheterozygoteEarly adult3.54x10-6 
embryonic lethality prior to organogenesis1 supporting datasetRecql4tm1.1(KOMP)VlcghomozygoteE9.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Recql4tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Recql4tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Recql4tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Recql4tm3(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell

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