Tmem115 | transmembrane protein 115

GeneMGI:1930765Synonyms: Pl6

Physiological systems

22 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Mortality/aging Renal/urinary system

18 No significant impact

2 Not tested

Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
51Embryo tissues

Phenotypes

preweaning lethality, complete penetrance1 supporting datasetTmem115tm1(KOMP)VlcghomozygoteEarly adultN/A * 
increased kidney weight2 supporting datasetsTmem115tm1(KOMP)VlcgheterozygoteEarly adult3.75x10-6 
increased lean body mass1 supporting datasetTmem115tm1(KOMP)VlcgheterozygoteEarly adult4.86x10-5 
edema1 supporting datasetTmem115tm1.1(KOMP)VlcghomozygoteE15.5N/A * 
increased circulating bilirubin level1 supporting datasetTmem115tm1(KOMP)VlcgheterozygoteEarly adult5.83x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Tmem115tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Tmem115tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse

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