Krit1 | KRIT1, ankyrin repeat containing

GeneMGI:1930618Synonyms: Ccm1, 2010007K12Rik, +4 more

Physiological systems

22 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Embryo Growth/size/body region Nervous system Vision/eye Hearing/vestibular/ear Behavior/neurological Cardiovascular system Mortality/aging Craniofacial

11 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:23Significant phenotypes

2Associated diseases

Expression examined in:73Adult tissues

49Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



embryonic lethality prior to tooth bud stage	1 supporting dataset	Krit1^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
abnormal neural tube closure	1 supporting dataset	Krit1^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
abnormal allantois morphology	1 supporting dataset	Krit1^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
abnormal otic vesicle morphology	1 supporting dataset	Krit1^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
abnormal embryo turning	1 supporting dataset	Krit1^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
abnormal blood vessel morphology	1 supporting dataset	Krit1^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
abnormal left-right axis patterning	1 supporting dataset	Krit1^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
abnormal somite shape	1 supporting dataset	Krit1^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
abnormal heart looping	1 supporting dataset	Krit1^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
abnormal embryo size	1 supporting dataset	Krit1^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Krit1.

Associated images

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Histopathology

There is no histopathology data found for Krit1.

IMPC related publications

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External links

No external links available for Krit1.

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*Krit1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Krit1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Krit1^{tm94595(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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