Clcf1 | cardiotrophin-like cytokine factor 1

GeneMGI:1930088Synonyms: Bsf3, CLC, +1 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Immune system Hematopoietic system Skeleton Mortality/aging Cardiovascular system

14 No significant impact

5 Not tested

Gene metrics:5Significant phenotypes
3Associated diseases
Expression examined in:44Adult tissues
50Embryo tissues

Phenotypes

increased bone mineral content1 supporting datasetClcf1tm1.1(KOMP)VlcgheterozygoteEarly adult4.71x10-5 
increased bone mineral density1 supporting datasetClcf1tm1.1(KOMP)VlcgheterozygoteEarly adult7.8x10-6 
prolonged QT interval1 supporting datasetClcf1tm1.1(KOMP)VlcgheterozygoteEarly adult1.35x10-5 
preweaning lethality, complete penetrance3 supporting datasetsClcf1tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
decreased leukocyte cell number1 supporting datasetClcf1tm1.1(KOMP)VlcgheterozygoteEarly adult8.62x10-5 
preweaning lethality, complete penetrance1 supporting datasetClcf1em1(IMPC)JhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Clcf1em1(IMPC)JExon Deletionmouse
Clcf1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Clcf1tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Clcf1tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell

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