Bcl11b | B cell leukemia/lymphoma 11B

GeneMGI:1929913Synonyms: 9130430L19Rik, COUP-TF interacting protein 2, +3 more

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Vision/eye Behavior/neurological Skeleton Mortality/aging Craniofacial

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

3Associated diseases

Expression examined in:48Adult tissues

50Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased bone mineral content	2 supporting datasets	Bcl11b^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	2.38x10^-5
abnormal eyelid fusion	1 supporting dataset	Bcl11b^{tm1.1(KOMP)Vlcg}	homozygote	E18.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Bcl11b^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal facial morphology	1 supporting dataset	Bcl11b^{tm1.1(KOMP)Vlcg}	homozygote	E18.5	N/A ^*
abnormal bone structure	1 supporting dataset	Bcl11b^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	7.06x10^-6
increased fasting circulating glucose level	1 supporting dataset	Bcl11b^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	7.69x10^-5
increased vertical activity	1 supporting dataset	Bcl11b^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	5.28x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Bcl11b.

Associated images

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Histopathology

There is no histopathology data found for Bcl11b.

IMPC related publications

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External links

No external links available for Bcl11b.

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*Bcl11b^tm1(KOMP)Mbp*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Bcl11b^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Bcl11b^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse

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