Smoc2 | SPARC related modular calcium binding 2

GeneMGI:1929881Synonyms: Smoc2l, 1700056C05Rik, +1 more

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Integument Growth/size/body region Skeleton

14 No significant impact

6 Not tested

Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
48Embryo tissues

Phenotypes

decreased bone mineral content2 supporting datasetsSmoc2tm1.1(KOMP)VlcghomozygoteEarly adult2.39x10-7 
increased circulating sodium level1 supporting datasetSmoc2tm1.1(KOMP)VlcghomozygoteEarly adult4.82x10-5 
abnormal coat appearance2 supporting datasetsSmoc2tm1.1(KOMP)VlcghomozygoteEarly adult1.21x10-5 
decreased body length1 supporting datasetSmoc2tm1.1(KOMP)VlcghomozygoteEarly adult1.26x10-24 
decreased bone mineral density1 supporting datasetSmoc2tm1.1(KOMP)VlcghomozygoteEarly adult1.9x10-6 
increased circulating phosphate level1 supporting datasetSmoc2tm1.1(KOMP)VlcghomozygoteEarly adult1.69x10-6 
abnormal bone structure1 supporting datasetSmoc2tm1.1(KOMP)VlcghomozygoteEarly adult1.39x10-12 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Smoc2tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Smoc2tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Smoc2tm453184(L1L2_GT0_LF2A_LacZ_BetactP_neo)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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