Asb2 | ankyrin repeat and SOCS box-containing 2

GeneMGI:1929743Synonyms: 1110008E15Rik

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Immune system Adipose tissue Embryo Growth/size/body region Vision/eye Hematopoietic system Cardiovascular system Mortality/aging

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

64Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal embryo size	1 supporting dataset	Asb2^{tm2b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
decreased total body fat amount	1 supporting dataset	Asb2^{tm2b(KOMP)Wtsi}	heterozygote	Early adult	6.11x10^-5
abnormal vitelline vasculature morphology	1 supporting dataset	Asb2^{tm2b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
increased Ly6C-positive immature NK cell number	1 supporting dataset	Asb2^{tm2b(KOMP)Wtsi}	heterozygote	Early adult	0
abnormal retina blood vessel morphology	1 supporting dataset	Asb2^{tm2b(KOMP)Wtsi}	heterozygote	Early adult	1.13x10^-5
embryonic growth retardation	1 supporting dataset	Asb2^{tm2b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
pale yolk sac	1 supporting dataset	Asb2^{tm2b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
increased lean body mass	1 supporting dataset	Asb2^{tm2b(KOMP)Wtsi}	heterozygote	Early adult	9.87x10^-5
decreased Ly6C-positive immature NK cell number	1 supporting dataset	Asb2^{tm2b(KOMP)Wtsi}	heterozygote	Early adult	7x10^-12
abnormal pericardium morphology	1 supporting dataset	Asb2^{tm2b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Asb2.

Associated images

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Histopathology

There is no histopathology data found for Asb2.

IMPC related publications

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External links

No external links available for Asb2.

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*Asb2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Asb2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Asb2^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Asb2^{tm2b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Asb2^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Asb2^{tm41925(L1L2_gt2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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