Pex3 | peroxisomal biogenesis factor 3

GeneMGI:1929646Synonyms: 1700014F15Rik, 2900010N04Rik, +1 more

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Limbs/digits/tail Vision/eye Skeleton Cardiovascular system

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:20Significant phenotypes

5Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased bone mineral density	1 supporting dataset	Pex3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.53x10^-11
cornea vascularization	1 supporting dataset	Pex3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.56x10^-5
increased bone mineral content	1 supporting dataset	Pex3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.1x10^-5
abnormal tail morphology	1 supporting dataset	Pex3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.01x10^-6
decreased body weight	4 supporting datasets	Pex3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	9.93x10^-7
increased heart weight	1 supporting dataset	Pex3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	9.39x10^-6
decreased circulating LDL cholesterol level	1 supporting dataset	Pex3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.97x10^-7
abnormal eye morphology	1 supporting dataset	Pex3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.58x10^-7
decreased total body fat amount	1 supporting dataset	Pex3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.17x10^-10
abnormal vertebrae morphology	1 supporting dataset	Pex3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.16x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pex3.

Associated images

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Histopathology

There is no histopathology data found for Pex3.

IMPC related publications

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External links

No external links available for Pex3.

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*Pex3^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Pex3^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pex3^{tm40041(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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