Orc6 | origin recognition complex, subunit 6

GeneMGI:1929285Synonyms: Orc6l, 6720420I10Rik

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Vision/eye Behavior/neurological Mortality/aging

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

impaired pupillary reflex1 supporting datasetOrc6em1(IMPC)JheterozygoteEarly adult1.28x10-8 
embryonic lethality prior to organogenesis1 supporting datasetOrc6em1(IMPC)JhomozygoteE9.5N/A * 
decreased circulating creatinine level1 supporting datasetOrc6em1(IMPC)JheterozygoteEarly adult9.2x10-5 
persistence of hyaloid vascular system1 supporting datasetOrc6em1(IMPC)JheterozygoteEarly adult9.21x10-5 
preweaning lethality, complete penetrance1 supporting datasetOrc6em1(IMPC)JhomozygoteEarly adultN/A * 
hyperactivity1 supporting datasetOrc6em1(IMPC)JheterozygoteEarly adult8.94x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Orc6em1(IMPC)JExon Deletionmouse

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