Snd1 | staphylococcal nuclease and tudor domain containing 1

GeneMGI:1929266Synonyms: p100 co-activator, Tudor-SN

Physiological systems

21 / 24 physiological systems tested

10 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Vision/eye Hematopoietic system Skeleton Mortality/aging Renal/urinary system

11 No significant impact

3 Not tested

Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, incomplete penetrance3 supporting datasetsSnd1em1(IMPC)TcphomozygoteEarly adultN/A * 
increased circulating alanine transaminase level1 supporting datasetSnd1em1(IMPC)TcpheterozygoteEarly adult6.71x10-11 
small thymus1 supporting datasetSnd1em1(IMPC)TcpheterozygoteLate adultN/A * 
cataract1 supporting datasetSnd1em1(IMPC)TcpheterozygoteEarly adult8.55x10-5 
abnormal sternum morphology1 supporting datasetSnd1em1(IMPC)TcphomozygoteEarly adultN/A * 
decreased spleen weight1 supporting datasetSnd1em1(IMPC)TcpheterozygoteLate adult4.63x10-6 
enlarged urinary bladder1 supporting datasetSnd1em1(IMPC)TcpheterozygoteEarly adultN/A * 
decreased body length1 supporting datasetSnd1em1(IMPC)TcpheterozygoteEarly adult7.07x10-5 
abnormal sternum morphology1 supporting datasetSnd1em1(IMPC)TcpheterozygoteLate adultN/A * 
decreased lymphocyte cell number1 supporting datasetSnd1em1(IMPC)TcpheterozygoteEarly adult2.07x10-12 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Snd1em1(IMPC)TcpExon Deletionmouse

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