Tsc1 | TSC complex subunit 1

GeneMGI:1929183Synonyms: tuberous sclerosis 1, hamartin

Physiological systems

22 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Immune system Endocrine/exocrine gland Vision/eye Hematopoietic system Mortality/aging Cardiovascular system

16 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

7Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Tsc1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal retina vasculature morphology	1 supporting dataset	Tsc1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	1.11x10^-7
enlarged thymus	1 supporting dataset	Tsc1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Tsc1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tsc1.

Associated images

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Histopathology

There is no histopathology data found for Tsc1.

IMPC related publications

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External links

No external links available for Tsc1.

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*Tsc1^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Tsc1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Tsc1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Tsc1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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