Pdzk1 | PDZ domain containing 1

GeneMGI:1928901Synonyms: 4921513F16Rik, Nherf3, +4 more

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Mortality/aging

16 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased circulating cholesterol level	1 supporting dataset	Pdzk1^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	7.61x10^-7
increased circulating LDL cholesterol level	1 supporting dataset	Pdzk1^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	1.13x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Pdzk1^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating HDL cholesterol level	1 supporting dataset	Pdzk1^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	1.71x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pdzk1.

Associated images

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Histopathology

There is no histopathology data found for Pdzk1.

IMPC related publications

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External links

No external links available for Pdzk1.

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*Pdzk1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Pdzk1^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Pdzk1^{tm2b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pdzk1^{tm3a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell

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