Svep1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1

GeneMGI:1928849Synonyms: 4833413O10Rik, 1110021D17Rik, +2 more

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Limbs/digits/tail Hematopoietic system Mortality/aging Cardiovascular system

15 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



edema	1 supporting dataset	Svep1^{tm1b(EUCOMM)Hmgu}	homozygote	E18.5	N/A ^*
abnormal skin appearance	1 supporting dataset	Svep1^{tm1b(EUCOMM)Hmgu}	homozygote	E18.5	N/A ^*
decreased circulating glucose level	1 supporting dataset	Svep1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.64x10^-5
abnormal tail morphology	1 supporting dataset	Svep1^{tm1b(EUCOMM)Hmgu}	homozygote	E18.5	N/A ^*
edema	1 supporting dataset	Svep1^{tm1b(EUCOMM)Hmgu}	homozygote	E15.5	N/A ^*
increased hemoglobin content	1 supporting dataset	Svep1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.67x10^-5
prolonged QRS complex duration	1 supporting dataset	Svep1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	9.1x10^-5
decreased circulating phosphate level	1 supporting dataset	Svep1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.81x10^-6
increased erythrocyte cell number	1 supporting dataset	Svep1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.93x10^-5
decreased circulating sodium level	1 supporting dataset	Svep1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.69x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Svep1.

Associated images

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Histopathology

There is no histopathology data found for Svep1.

IMPC related publications

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External links

No external links available for Svep1.

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*Svep1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Svep1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Svep1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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