Pfdn5 | prefoldin 5

GeneMGI:1928753Synonyms: 1700010A06Rik, EIG-1, +4 more

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Adipose tissue Embryo Growth/size/body region Limbs/digits/tail Mortality/aging Craniofacial

13 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:50Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal craniofacial morphology	1 supporting dataset	Pfdn5^{tm1b(EUCOMM)Wtsi}	homozygote	E15.5	N/A ^*
decreased lean body mass	1 supporting dataset	Pfdn5^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	4.92x10^-5
increased total body fat amount	2 supporting datasets	Pfdn5^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.88x10^-5
preweaning lethality, complete penetrance	3 supporting datasets	Pfdn5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
prenatal lethality	1 supporting dataset	Pfdn5^{tm1b(EUCOMM)Wtsi}	homozygote	E18.5	N/A ^*
abnormal embryo size	1 supporting dataset	Pfdn5^{tm1b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
edema	1 supporting dataset	Pfdn5^{tm1b(EUCOMM)Wtsi}	homozygote	E15.5	N/A ^*
abnormal skin coloration	1 supporting dataset	Pfdn5^{tm1b(EUCOMM)Wtsi}	homozygote	E15.5	N/A ^*
abnormal tail morphology	1 supporting dataset	Pfdn5^{tm1b(EUCOMM)Wtsi}	homozygote	E15.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Pfdn5^{tm1b(EUCOMM)Wtsi}	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pfdn5.

Associated images

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Histopathology

There is no histopathology data found for Pfdn5.

IMPC related publications

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External links

No external links available for Pfdn5.

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*Pfdn5^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pfdn5^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pfdn5^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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