Tdo2 | tryptophan 2,3-dioxygenase

GeneMGI:1928486Synonyms: TDO, TO, +1 more

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Nervous system Vision/eye Mortality/aging Cardiovascular system

12 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



edema	1 supporting dataset	Tdo2^{tm1b(KOMP)Mbp}	homozygote	E15.5	N/A ^*
preweaning lethality, incomplete penetrance	2 supporting datasets	Tdo2^{tm1b(KOMP)Mbp}	homozygote	Early adult	N/A ^*
increased heart weight	2 supporting datasets	Tdo2^{tm1b(KOMP)Mbp}	heterozygote	Early adult	2x10^-5
increased prepulse inhibition	1 supporting dataset	Tdo2^{tm1b(KOMP)Mbp}	heterozygote	Early adult	1.78x10^-6
microphthalmia	1 supporting dataset	Tdo2^{tm1b(KOMP)Mbp}	homozygote	E15.5	N/A ^*
enlarged heart	1 supporting dataset	Tdo2^{tm1b(KOMP)Mbp}	heterozygote	Early adult	N/A ^*
abnormal heart morphology	1 supporting dataset	Tdo2^{tm1b(KOMP)Mbp}	heterozygote	Early adult	N/A ^*
abnormal embryo size	1 supporting dataset	Tdo2^{tm1b(KOMP)Mbp}	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tdo2.

Associated images

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Histopathology

There is no histopathology data found for Tdo2.

IMPC related publications

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External links

No external links available for Tdo2.

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*Tdo2^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Tdo2^{tm1b(KOMP)Mbp}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Tdo2^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell
*Tdo2^{tm2a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Tdo2^{tm2e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell
*Tdo2^{tm41820(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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