Inpp5e | inositol polyphosphate-5-phosphatase E

GeneMGI:1927753Synonyms: 1200002L24Rik, 72kDa

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Craniofacial Mortality/aging Cardiovascular system

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

6Associated diseases

Expression examined in:73Adult tissues

50Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



anophthalmia	1 supporting dataset	Inpp5e^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
abnormal neural tube closure	1 supporting dataset	Inpp5e^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
abnormal craniofacial morphology	1 supporting dataset	Inpp5e^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
microphthalmia	1 supporting dataset	Inpp5e^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
abnormal hindbrain morphology	1 supporting dataset	Inpp5e^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
polydactyly	1 supporting dataset	Inpp5e^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Inpp5e^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal embryo size	1 supporting dataset	Inpp5e^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
edema	1 supporting dataset	Inpp5e^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
abnormal forebrain morphology	1 supporting dataset	Inpp5e^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Inpp5e.

Associated images

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Histopathology

There is no histopathology data found for Inpp5e.

IMPC related publications

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External links

No external links available for Inpp5e.

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*Inpp5e^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Inpp5e^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Inpp5e^{tm252808(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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