Sirt3 | sirtuin 3
Physiological systems
20 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Behavior/neurological Skeleton
17 No significant impact
4 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues
| vertebral fusion | 1 supporting dataset | Sirt3tm1b(EUCOMM)Wtsi | homozygote | Early adult | 7.73x10-7 | ||
| increased circulating creatine kinase level | 1 supporting dataset | Sirt3tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.55x10-7 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Sirt3tm1b(EUCOMM)Wtsi | homozygote | Early adult | 6.72x10-6 | ||
| abnormal gait | 1 supporting dataset | Sirt3tm1b(EUCOMM)Wtsi | homozygote | Early adult | 8.49x10-7 |
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External links
No external links available for Sirt3.
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| Sirt3tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | es cell |
| Sirt3tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector es cell mouse |
| Sirt3tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Sirt3tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | es cell |
| Sirt3tm47264(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |