Sirt2 | sirtuin 2

GeneMGI:1927664Synonyms: SIR2L2, Sir2l, +1 more

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Cardiovascular system

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:2Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased heart weight	1 supporting dataset	Sirt2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.27x10^-5
increased circulating creatinine level	1 supporting dataset	Sirt2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	9.47x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sirt2.

Associated images

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Histopathology

There is no histopathology data found for Sirt2.

IMPC related publications

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External links

No external links available for Sirt2.

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*Sirt2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Sirt2^{tm39885(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes