Sirt2 | sirtuin 2

GeneMGI:1927664Synonyms: SIR2L2, Sir2l, +1 more

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Cardiovascular system

17 No significant impact

4 Not tested

Gene metrics:2Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

increased heart weight1 supporting datasetSirt2tm1a(EUCOMM)WtsihomozygoteEarly adult8.27x10-5 
increased circulating creatinine level1 supporting datasetSirt2tm1a(EUCOMM)WtsihomozygoteEarly adult9.47x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Sirt2tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Sirt2tm39885(L1L2_gt0)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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