Irx6 | Iroquois homeobox 6

GeneMGI:1927642

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Pigmentation Integument Endocrine/exocrine gland Vision/eye Liver/biliary system

12 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



abnormal coat/hair pigmentation	2 supporting datasets	Irx6^{tm1b(KOMP)Mbp}	homozygote	Late adult	8.58x10^-7
abnormal seminal vesicle morphology	1 supporting dataset	Irx6^{tm1b(KOMP)Mbp}	homozygote	Late adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Irx6^{tm1b(KOMP)Mbp}	homozygote	Early adult	N/A ^*
abnormal skin coloration	1 supporting dataset	Irx6^{tm1b(KOMP)Mbp}	homozygote	Late adult	1.69x10^-7
increased circulating phosphate level	1 supporting dataset	Irx6^{tm1b(KOMP)Mbp}	homozygote	Early adult	3.2x10^-6
abnormal liver morphology	1 supporting dataset	Irx6^{tm1b(KOMP)Mbp}	homozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Irx6.

Associated images

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Histopathology

There is no histopathology data found for Irx6.

IMPC related publications

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External links

No external links available for Irx6.

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*Irx6^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Irx6^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Irx6^{tm1b(KOMP)Mbp}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Irx6^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell
*Irx6^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Irx6^{tm2a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Irx6^{tm2e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell
*Irx6^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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