Diaph3 | diaphanous related formin 3

GeneMGI:1927222Synonyms: 4930417P13Rik, Diap3, +3 more

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Embryo Growth/size/body region Vision/eye Hematopoietic system Cardiovascular system Mortality/aging Craniofacial

11 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

2Associated diseases

Expression examined in:48Adult tissues

50Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased circulating triglyceride level	1 supporting dataset	Diaph3^{tm1b(KOMP)Mbp}	heterozygote	Early adult	3.19x10^-6
mydriasis	1 supporting dataset	Diaph3^{tm1b(KOMP)Mbp}	heterozygote	Late adult	8.21x10^-7
embryonic growth retardation	1 supporting dataset	Diaph3^{tm1b(KOMP)Mbp}	homozygote	E9.5	N/A ^*
decreased circulating free fatty acids level	1 supporting dataset	Diaph3^{tm1b(KOMP)Mbp}	heterozygote	Early adult	2.14x10^-7
abnormal embryo turning	1 supporting dataset	Diaph3^{tm1b(KOMP)Mbp}	homozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Diaph3^{tm1b(KOMP)Mbp}	homozygote	Early adult	N/A ^*
decreased mean corpuscular volume	1 supporting dataset	Diaph3^{tm1b(KOMP)Mbp}	heterozygote	Early adult	5.27x10^-5
abnormal embryo size	1 supporting dataset	Diaph3^{tm1b(KOMP)Mbp}	homozygote	E9.5	N/A ^*
pallor	1 supporting dataset	Diaph3^{tm1b(KOMP)Mbp}	homozygote	E12.5	N/A ^*
abnormal craniofacial morphology	1 supporting dataset	Diaph3^{tm1b(KOMP)Mbp}	homozygote	E12.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

Rows per page:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Diaph3.

Associated images

Loading...

Histopathology

There is no histopathology data found for Diaph3.

IMPC related publications

Loading...

External links

No external links available for Diaph3.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Diaph3^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Diaph3^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Diaph3^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Diaph3^{tm1b(KOMP)Mbp}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Diaph3^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell

My Genes