Mettl3 | methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit

GeneMGI:1927165Synonyms: Spo8, 2310024F18Rik, +1 more

Physiological systems

19 / 24 physiological systems tested

1 Significantly impacted by the knock-out

Mortality/aging

18 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Mettl3^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Mettl3^em1(IMPC)Tcp	homozygote	E9.5	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Mettl3^em1(IMPC)Tcp	homozygote	E12.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mettl3.

Associated images

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Histopathology

There is no histopathology data found for Mettl3.

IMPC related publications

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External links

No external links available for Mettl3.

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*Mettl3^em1(IMPC)Tcp*	Intra-exon deletion	‌	mouse
*Mettl3^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Mettl3^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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