Trpv4 | transient receptor potential cation channel, subfamily V, member 4

GeneMGI:1926945Synonyms: VR-OAC, OTRPC4, +4 more

Physiological systems

22 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Integument Endocrine/exocrine gland Liver/biliary system

17 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

20Associated diseases

Expression examined in:0Adult tissues

27Embryo tissues

Phenotypes

Phy. System:



abnormal liver morphology	1 supporting dataset	Trpv4^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal skin coloration	2 supporting datasets	Trpv4^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.6x10^-5
small liver	1 supporting dataset	Trpv4^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating glucose level	1 supporting dataset	Trpv4^{tm1a(KOMP)Wtsi}	homozygote	Early adult	3.38x10^-5
abnormal gallbladder morphology	1 supporting dataset	Trpv4^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal coat/hair pigmentation	4 supporting datasets	Trpv4^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.6x10^-5
small gallbladder	1 supporting dataset	Trpv4^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Trpv4.

Associated images

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Histopathology

There is no histopathology data found for Trpv4.

IMPC related publications

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External links

No external links available for Trpv4.

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*Trpv4^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Trpv4^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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