Postn | periostin, osteoblast specific factor

GeneMGI:1926321Synonyms: Osf2, peri, +3 more

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Hematopoietic system Behavior/neurological Skeleton

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

50Embryo tissues

Phenotypes

Phy. System:



abnormal bone structure	1 supporting dataset	Postn^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.93x10^-8
decreased body length	1 supporting dataset	Postn^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	6.28x10^-21
decreased bone mineral content	1 supporting dataset	Postn^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.41x10^-5
decreased bone mineral density	1 supporting dataset	Postn^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.65x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Postn^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	9.32x10^-10
increased grip strength	2 supporting datasets	Postn^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.52x10^-17
thrombocytosis	1 supporting dataset	Postn^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.77x10^-7
abnormal sleep behavior	3 supporting datasets	Postn^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	7.38x10^-10
increased bone mineral content	1 supporting dataset	Postn^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	4.55x10^-6
decreased thigmotaxis	2 supporting datasets	Postn^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	8.38x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Postn.

Associated images

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Histopathology

There is no histopathology data found for Postn.

IMPC related publications

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External links

No external links available for Postn.

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*Postn^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Postn^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Postn^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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