Tnip1 | TNFAIP3 interacting protein 1

GeneMGI:1926194Synonyms: ABIN1, Nef, +2 more

Physiological systems

16 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Behavior/neurological

11 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:25Significant phenotypes

1Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



decreased circulating serum albumin level	1 supporting dataset	Tnip1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.13x10^-11
decreased lymphocyte cell number	1 supporting dataset	Tnip1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.43x10^-8
increased red blood cell distribution width	1 supporting dataset	Tnip1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.27x10^-35
decreased erythrocyte cell number	1 supporting dataset	Tnip1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.08x10^-30
increased basophil cell number	1 supporting dataset	Tnip1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.81x10^-7
increased circulating alanine transaminase level	1 supporting dataset	Tnip1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.32x10^-88
increased large unstained cell number	2 supporting datasets	Tnip1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.3x10^-18
increased freezing behavior	2 supporting datasets	Tnip1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.68x10^-6
increased circulating aspartate transaminase level	1 supporting dataset	Tnip1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.75x10^-31
increased mean platelet volume	1 supporting dataset	Tnip1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.9x10^-49

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tnip1.

Associated images

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Histopathology

There is no histopathology data found for Tnip1.

IMPC related publications

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External links

No external links available for Tnip1.

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*Tnip1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Tnip1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Tnip1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Tnip1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Tnip1^{tm33632(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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