Nadsyn1 | NAD synthetase 1

GeneMGI:1926164Synonyms: 9130012B15Rik

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Reproductive system Immune system Growth/size/body region Vision/eye Respiratory system Hematopoietic system Behavior/neurological Cardiovascular system

13 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

2Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



enlarged spleen	1 supporting dataset	Nadsyn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased heart rate	1 supporting dataset	Nadsyn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.66x10^-7
female infertility	1 supporting dataset	Nadsyn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
prolonged RR interval	1 supporting dataset	Nadsyn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.4x10^-9
decreased pulmonary ventilation	1 supporting dataset	Nadsyn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.5x10^-5
cornea opacity	1 supporting dataset	Nadsyn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.48x10^-6
prolonged ST segment	1 supporting dataset	Nadsyn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	8.15x10^-5
decreased grip strength	1 supporting dataset	Nadsyn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	8.08x10^-6
cornea vascularization	1 supporting dataset	Nadsyn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.24x10^-8
increased pulmonary ventilation	1 supporting dataset	Nadsyn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.42x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nadsyn1.

Associated images

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Histopathology

There is no histopathology data found for Nadsyn1.

IMPC related publications

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External links

No external links available for Nadsyn1.

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*Nadsyn1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Nadsyn1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Nadsyn1^{tm44427(L1L2_gt2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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